Wnt signaling is conventionally divided into the canonical pathway that utilizes b-catenin to control gene expression, versus noncanonical mechanisms that involve other signaling intermediates such as the Rho family of small GTPases (e.g., Rac1) to control cell morphology and behavior. Dr. Fanxin Long will discuss their recent studies that Wnt-induced Rac1 and subsequent JNK activation controls the nuclear localization of b-catenin through direct and specific phosphorylation of the b-catenin molecule. These results therefore challenge the conventional division of canonical versus noncanonical pathways.
Fanxin Long (2008). When the gut talks to bone. Cell 135, 795-6. PMID: 19041744.
Fanxin Long (2008). Targeting intercellular signals for bone regeneration from bone marrow mesenchymal progenitors. Cell Cycle 7, 1-6. PMID: 18635951.
Ximei Wu, Xiaolin Tu, Kyu Sang Joeng, Matthew J. Hilton, David A. Williams, Fanxin Long (2008). Rac1 activation controls nuclear localization of b-catenin during canonical Wnt signaling. Cell 133, 340-53. PMID: 18423204.
Matthew J. Hilton, Xiaolin Tu, Ximei Wu, Shuting Bai, Haibo Zhao, Tatsuya Kobayashi, Henry M. Kronenberg, Steven L. Teitelbaum, F. Patrick Ross, Raphael Kopan, Fanxin Long (2008). Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat. Med. 14, 306-14. PMID: 18297083.